Structured Profile. A set of 8 aligned structured motifs yield the initial profile motif = M1 [0, 5] M2 [0, 9] M3, (where |M1| = 4, |M2| = 6, and |M3| = 5), which is converted into the information content weighted profile . The highest weights at each position are given in bold. The penultimate row shows the position specific information content (IC), and the core positions with highest IC are given in brackets. The last row shows the IUPAC symbol that best captures the position specific symbol occurrences.