Figure 1

Probability distribution for correlation (Pearson) between a random pair and known gene/TF regulatory interaction for E. coli. Square markers refer to the dataset obtained from the U. of Oklahoma E. coli database. Diamond markers refer to the datasets obtained from the NIH omnibus service (GSE7, GSE8, GSE9; 65 datasets). The solid and hollow markers show the probability distribution for correlation between a random gene pair and known gene/TF regulatory interaction, respectively. As these probability distributions are indistinguishable, it does not seem feasible to construct the TRN using expression data alone. We also calculated probability distributions for mutual information which yielded similar findings.