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Table 1 Sum-of-pairs scores of various alignment programs on the benchmark database IRMBASE 2

From: DIALIGN-TX: greedy and progressive approaches for segment-based multiple sequence alignment

Method (Protein)

REF1

REF2

REF3

REF4

Total

DIALIGN-TX

89.42

94.90

93.75

93.64

92.93

DIALIGN-T 0.2.2

89.670

94.190

93.93 0

93.120

92.730

DIALIGN 2.2

90.430

93.40-

91.78--

92.98-

92.15--

CLUSTAL W2

07.13--

10.63--

19.87--

26.17--

15.95--

T-COFFEE 5.56

72.67--

77.80--

83.03--

83.48-

79.24--

POA V2

87.56-

49.57--

41.90--

37.56--

54.15--

MAFFT 6.240 L-INSi

82.780

84.29-

84.15--

82.42--

84.41--

MAFFT 6.240 E-INSi

90.53 0

94.370

93.110

94.79 +

93.20 +

MUSCLE 3.7

32.67--

34.82--

54.19--

57.84--

44.88--

PROBCONS 1.12

78.78--

86.82--

87.29-

87.69--

85.15--

  1. Average sum-of-pair scores (SPS) of the benchmarked programs on the core blocks (given by the implanted conserved motifs) of IRMBASE 2. Minus symbols denote statistically significant inferiority of the respective method compared with DIALIGN-TX, while plus symbols denote statistically significant superiority of the method. 0 denotes non-significant superiority or inferiority of DIALIGN-TX, respectively. Single plus or minus symbols denote significance according to the Wilcoxon Matched Pairs Signed Rank Test with p ≤ 0.05 and double symbols denote significance with p ≤ 0.001, respectively.