Modeling genetic imprinting effects of DNA sequences with multilocus polymorphism data

Table 1 Sex-specific differences observed in haplotype frequencies and higher-order linkage disequilibria estimates

	Male		Female		Sex-specific	Sex-specific
Genetic Parameter	MLE	p-value	MLE	p-value	LR	p-value
Haplotype Frequency
GAC	0.780		0.764
GAT	0.000		0.000
GGC	0.124		0.081
GGT	0.011		0.023
TAC	0.049		0.104
TAT	0.000		0.000
TGC	0.008		0.000
TGT	0.030		0.029
Allele Frequency and Linkage Disequilibrium
G (OPRKG36T)	0.914		0.868		6.166	0.0130
A (OPRKA843G)	0.828		0.868		3.501	0.0613
A (OPRKC846T)	0.960		0.949		2.943	0.0862
₁₂	0.034	0.0459	0.045	0.1812	5.771	0.0163
₂₃	0.026	4.98e^-6	0.022	3.61e^-6	42.281	7.91^e-11
₁₃	0.023	8.87e^-5	0.011	0.0089	22.216	2.44e^-6
₁₂₃	-0.021	2.53e^-4	-0.018	0.0055	21.088	4.39e^-6

Estimates and tests of population genetic structure for three SNPs, OPRKG36T (with two alleles G and T), OPRKA843G (with alleles A and G), and OPRKC846T (with alleles C and T), at the kappa-opioid receptor in males and females.

ISSN: 1748-7188