Generated case showing success for DoPloCompare. Structural element taken from a generated set of secondary structures with uniform probability. (A) The desired secondary structure for which the algorithm tries to design a sequence. (B) The exact solution found when using the modified RNAinverse with DoPloCompare distance. (C) The closest secondary structure the algorithm returns after 500 iterations, when using the original RNAinverse with base-pairing distance.