TY - JOUR AU - Salem, Saeed AU - Zaki, Mohammed J. AU - Bystroff, Chris PY - 2010 DA - 2010/01/04 TI - FlexSnap: Flexible Non-sequential Protein Structure Alignment JO - Algorithms for Molecular Biology SP - 12 VL - 5 IS - 1 AB - Proteins have evolved subject to energetic selection pressure for stability and flexibility. Structural similarity between proteins that have gone through conformational changes can be captured effectively if flexibility is considered. Topologically unrelated proteins that preserve secondary structure packing interactions can be detected if both flexibility and Sequential permutations are considered. We propose the FlexSnap algorithm for flexible non-topological protein structural alignment. SN - 1748-7188 UR - https://doi.org/10.1186/1748-7188-5-12 DO - 10.1186/1748-7188-5-12 ID - Salem2010 ER -