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Figure 4 | Algorithms for Molecular Biology

Figure 4

From: An automated stochastic approach to the identification of the protein specificity determinants and functional subfamilies

Figure 4

(A) Mapping of the predicted SDPs onto the catalytic domain of PDE4 D (PDB ID 1TFB). AMP colored blue, SDPs shown as spheres, SDPs located in the hydrophobic ligand-binding pocket colored red, SDPs located on the other side of bimetallic cluster colored yellow. (B) Superposition of sildenafil molecules in active sites of PDE4B (cyan) and PDE5A (green). Sildenafil bound to PDE4B is colored blue, and bound to PDE5A is dark green.

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Algorithms for Molecular Biology

ISSN: 1748-7188