From: Survival associated pathway identification with group L p penalized global AUC maximization
w i | GeneID | Gene Name |
---|---|---|
ECM-receptor interaction (relevance counts: 200) | ||
0.2239 | CD36 | cd36 antigen (collagen type i receptor, thrombospondin receptor) |
0.0409 | FNDC1 | fibronectin type iii domain containing 1 |
0.0746 | SV2C | synaptic vesicle glycoprotein 2c |
0.0804 | SDC1 | syndecan 1 |
-0.1255 | FN1 | fibronectin 1 |
0.0211 | LAMC1 | laminin, gamma 1 (formerly lamb2) |
-0.0854 | GP5 | glycoprotein v (platelet) |
-0.1130 | CD47 | cd47 antigen (rh-related antigen, integrin-associated signal transducer) |
-0.1296 | THBS2 | thrombospondin 2 |
-0.0547 | COL1A2 | collagen, type i, alpha 2 |
-0.1024 | COL5A2 | collagen, type v, alpha 2 |
0.0861 | LAMB4 | laminin, beta 4 |
-0.0315 | COL1A1 | collagen, type i, alpha 1 |
0.0395 | AGRN | agrin RG |
Focal adhesion (relevance counts 145) | ||
0.0054 | PAK3 | p21 (cdkn1a)-activated kinase 3 |
0.0446 | PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) |
0.0044 | PDPK1 | 3-phosphoinositide dependent protein kinase-1 |
-0.0045 | BAD | bcl2-antagonist of cell death |
0.0087 | PARVA | parvin, alpha |
-0.0144 | FN1 | fibronectin 1 |
0.0041 | LAMC1 | laminin, gamma 1 (formerly lamb2) |
-0.0202 | PARVG | parvin, gamma |
-0.0158 | THBS2 | thrombospondin 2 |
0.0134 | PPP1R12A | protein phosphatase 1, regulatory (inhibitor) subunit 12a |
-0.0044 | SOS1 | son of sevenless homolog 1 (drosophila) |
-0.0084 | COL1A2 | collagen, type i, alpha 2 |
-0.0122 | COL5A2 | collagen, type v, alpha 2 |
0.0091 | LAMB4 | laminin, beta 4 RG Homo sapiens |
-0.0068 | RAF1 | v-raf-1 murine leukemia viral oncogene homolog 1 |
-0.0038 | ACTN1 | actinin, alpha 1 |
-0.0034 | COL1A1 | collagen, type i, alpha 1 |
-0.0067 | GSK3B | glycogen synthase kinase 3 beta |
-0.0065 | MAPK8 | mitogen-activated protein kinase 8 |
-0.0030 | MYL7 | myosin, light polypeptide 7, regulatory |
Neuroactive ligand-receptor interaction (relevance counts: 200) | ||
0.0894 | P2RY6 | pyrimidinergic receptor p2y, g-protein coupled, 6 |
-0.2753 | PTAFR | platelet-activating factor receptor |
0.1648 | GLRA3 | glycine receptor, alpha 3 |
0.0857 | FPRL1 | formyl peptide receptor-like 1 |
-0.1783 | EDNRA | endothelin receptor type a |
0.3233 | HRH4 | histamine receptor h4 |
0.2106 | GRM2 | glutamate receptor, metabotropic 2 |
-0.1112 | GRIN1 | glutamate receptor, ionotropic, n-methyl d-aspartate 1 |
-0.0220 | PTHR1 | parathyroid hormone receptor 1 |
0.0971 | OPRM1 | opioid receptor, mu 1 |
-0.4303 | CTSG | cathepsin g |
-0.0404 | P2RY8 | purinergic receptor p2y, g-protein coupled, 8 |
-0.0783 | BDKRB1 | bradykinin receptor b1 |
0.3247 | FSHR | follicle stimulating hormone receptor |
-0.1430 | ADRA1B | adrenergic, alpha-1b-, receptor |
0.1464 | C3AR1 | complement component 3a receptor 1 |
0.1120 | P2RX2 | purinergic receptor p2x, ligand-gated ion channel, 2 |
0.0311 | AVPR1B | arginine vasopressin receptor 1b |
0.2646 | FPR1 | formyl peptide receptor 1 |
0.2003 | GABRA5 | gamma-aminobutyric acid (gaba) a receptor, alpha 5 |
-0.0278 | PRLR | prolactin receptor |
-0.1070 | ADORA1 | adenosine a1 receptor |
0.2652 | HTR7 | 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled) |
-0.0194 | GABRA4 | gamma-aminobutyric acid (gaba) a receptor, alpha 4 |
0.0145 | GHRHR | growth hormone releasing hormone receptor |
-0.3163 | MAS1 | mas1 oncogene |
-0.0760 | PTGER3 | prostaglandin e receptor 3 (subtype ep3) |
0.2196 | PARD3 | par-3 partitioning defective 3 homolog (c. elegans) |
Ubiquitin mediated proteolysis (relevance counts: 200) | ||
0.0186 | UBE2B | ubiquitin-conjugating enzyme e2b (rad6 homolog) |
-0.0677 | CUL4A | cullin 4a |
0.0051 | PML | promyelocytic leukemia |
-0.1023 | UBE3B | ubiquitin protein ligase e3b |
-0.1581 | UBE3C | ubiquitin protein ligase e3c |
0.1390 | BTRC | beta-transducin repeat containing |
-0.0669 | HERC3 | hect domain and rld 3 |
0.00009 | RBX1 | ring-box 1 |
0.0011 | CUL5 | cullin 5 |
0.0267 | ANAPC4 | anaphase promoting complex subunit 4 |
-0.0253 | UBE2L3 | ubiquitin-conjugating enzyme e2l 3 |
0.0096 | KEAP1 | kelch-like ech-associated protein 1 |
-0.0267 | UBE2E1 | ubiquitin-conjugating enzyme e2e 1 (ubc4/5 homolog, yeast) |
0.0116 | CBL | cas-br-m (murine) ecotropic retroviral transforming sequence |
0.0328 | BIRC6 | baculoviral iap repeat-containing 6 (apollon) |
Porphyrin and chlorophyll metabolism (relevance counts: 185) | ||
0.0330 | BLVRA | biliverdin reductase a |
-0.0103 | FTH1 | ferritin, heavy polypeptide 1 |
0.0227 | ALAD | aminolevulinate, delta-, dehydratase |
0.1983 | HMOX1 | heme oxygenase (decycling) 1 |
0.0070 | UROS | uroporphyrinogen iii synthase (congenital erythropoietic porphyria) |
-0.1596 | GUSB | glucuronidase, beta |
0.0077 | UGT2B15 | udp glucuronosyltransferase 2 family, polypeptide b15 |
Calcium signaling pathway (relevance counts: 200) | ||
-0.0025 | BST1 | bone marrow stromal cell antigen 1 |
0.0003 | BDKRB1 | bradykinin receptor b1 |
-0.0016 | PTAFR | platelet-activating factor receptor |
-0.0002 | ADRA1B | adrenergic, alpha-1b-, receptor |
-0.0007 | PPP3CC | protein phosphatase 3 (formerly 2b), catalytic subunit, gamma isoform |
-0.0001 | ADCY7 | adenylate cyclase 7 |
0.0008 | GNA11 | guanine nucleotide binding protein (g protein), alpha 11 (gq class) |
-0.0013 | AVPR1B | arginine vasopressin receptor 1b |
0.0014 | P2RX2 | purinergic receptor p2x, ligand-gated ion channel, 2 |
-0.0013 | CACNA1E | calcium channel, voltage-dependent, alpha 1e subunit |
0.0004 | EDNRA | endothelin receptor type a |
0.00009 | SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 |
0.0006 | CACNA1B | calcium channel, voltage-dependent, l type, alpha 1b subunit |
-0.0013 | PLCD1 | phospholipase c, delta 1 |
-0.0029 | HTR7 | 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled) |
0.0014 | GRIN1 | glutamate receptor, ionotropic, n-methyl d-aspartate 1 |
0.0028 | CAMK2A | calcium/calmodulin-dependent protein kinase (cam kinase) ii alpha |
-0.0024 | CACNA1I | calcium channel, voltage-dependent, alpha 1i subunit |
-0.0002 | TNNC1 | troponin c type 1 (slow) |
0.0009 | PTGER3 | prostaglandin e receptor 3 (subtype ep3) |
0.0012 | CACNA1F | calcium channel, voltage-dependent, alpha 1f subunit |
Fatty acid metabolism (relevance counts: 192) | ||
0.0043 | ACSL3 | acyl-coa synthetase long-chain family member 3 |
0.0675 | ALDH2 | aldehyde dehydrogenase 2 family (mitochondrial) |
-0.0491 | ACAT2 | acetyl-coenzyme a acetyltransferase 2 (acetoacetyl coenzyme a thiolase) |
0.0120 | ALDH1B1 | aldehyde dehydrogenase 1 family, member b1 |
0.0597 | CYP4A11 | cytochrome p450, family 4, subfamily a, polypeptide 11 |
-0.1447 | ACADSB | acyl-coenzyme a dehydrogenase, short/branched chain |
0.0736 | CPT1A | carnitine palmitoyltransferase 1a (liver) |
0.1075 | CPT1B | carnitine palmitoyltransferase 1b (muscle) |
-0.0366 | ACADVL | acyl-coenzyme a dehydrogenase, very long chain |
0.2168 | ADH4 | alcohol dehydrogenase 4 (class ii), pi polypeptide |
MAPK signaling pathway (relevance counts: 200) | ||
-0.1570 | PLA2G10 | phospholipase a2, group x |
-0.2415 | MAPKAPK5 | mitogen-activated protein kinase-activated protein kinase 5 |
-0.1636 | IL1B | interleukin 1, beta |
-0.0651 | ZAK | sterile alpha motif and leucine zipper containing kinase azk |
0.0572 | PPP3CC | protein phosphatase 3 (formerly 2b), catalytic subunit, gamma isoform |
-0.0674 | MAP3K2 | mitogen-activated protein kinase kinase kinase 2 |
-0.1729 | JUND | jun d proto-oncogene |
-0.1718 | SOS1 | son of sevenless homolog 1 (drosophila) |
0.1082 | FGF14 | fibroblast growth factor 14 |
0.3102 | PTPN5 | protein tyrosine phosphatase, non-receptor type 5 |
-0.3903 | CACNB1 | calcium channel, voltage-dependent, beta 1 subunit |
0.2678 | MAP3K7 | mitogen-activated protein kinase kinase kinase 7 |
0.3176 | CACNG8 | calcium channel, voltage-dependent, gamma subunit 8 |
0.0893 | FGF19 | fibroblast growth factor 19 |
-0.0853 | RRAS2 | related ras viral (r-ras) oncogene homolog 2 |
0.0215 | NLK | nemo-like kinase |
0.0452 | MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 |
0.1639 | CACNA1E | calcium channel, voltage-dependent, alpha 1e subunit |
-0.0290 | ARRB1 | arrestin, beta 1 |
-0.1169 | STK4 | serine/threonine kinase 4 |
0.1008 | CACNA1B | calcium channel, voltage-dependent, l type, alpha 1b subunit |
0.0839 | MOS | v-mos moloney murine sarcoma viral oncogene homolog |
-0.1244 | MEF2C | mads box transcription enhancer factor 2, polypeptide c |
0.1572 | RAF1 | v-raf-1 murine leukemia viral oncogene homolog 1 |
0.1757 | MAPK8IP1 | mitogen-activated protein kinase 8 interacting protein 1 |
0.2908 | IKBKB | inhibitor of kappa light polypeptide gene enhancer in b-cells, kinase beta |
-0.3452 | CACNA1I | calcium channel, voltage-dependent, alpha 1i subunit |
-0.2473 | MAPK8 | mitogen-activated protein kinase 8 |
-0.2339 | CACNA1F | calcium channel, voltage-dependent, alpha 1f subunit |
0.0979 | CD14 | cd14 antigen |
-0.1047 | MRAS | muscle ras oncogene homolog |