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Figure 1 | Algorithms for Molecular Biology

Figure 1

From: Predicting direct protein interactions from affinity purification mass spectrometry data

Figure 1

Indirect interactions in AP-MS PPI data. In a cell, multiple copies of a bait protein b are expressed, and interact (directly or indirectly) with other proteins p1, ..., p8 (left); After the pull-down on the bait b, MS detects all prey proteins, including indirect interaction partners (top right); The direct interaction network should, however, contain only the edges between direct interaction partners (bottom right).

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