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Table 4 Comparison of our method to simple hill-climbing approach

From: Predicting direct protein interactions from affinity purification mass spectrometry data

Network Real Predicted FDR(%) FNR(%)
(i) Hill-climbing 1318 2108 86.67 78.68
(ii) Hill-climbing + weakly conn. nodes 1318 1517 43.57 35.05
(iii) Our approach (GA) 1318 1390 14.96 10.31
  1. Comparison of our method to simple hill-climbing approach. (i) accuracy of the hill-climbing approach used over the complete network; (ii) accuracy of the hill-climbing approach after fixing the weakly connected nodes using our algorithm; (iii) accuracy of our combined pipeline using the genetic algorithm.