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Figure 3 | Algorithms for Molecular Biology

Figure 3

From: Estimating the evidence of selection and the reliability of inference in unigenic evolution

Figure 3

The Expected Mutation Count Distribution for I-Bmol. The expected distribution of total nonsynonymous mutations per clone (κ) for I-Bmol under the null hypothesis of 'no selection', the observed mutation count frequencies for the unselected clones, and the observed mutation count frequencies for the selected clones under the alternate hypothesis. Over 96.7% of clones are expected to have between 4-16 nonsynonymous mutations, inclusive, within the 266 amino acid sites of I-Bmol. Expected and observed distributions under H0 were very similar, considering the sample size of 87 clones. The selected population, under H A , displayed a marked decrease in the number of mutations, with > 95% of clones having seven or fewer mutations.

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