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Figure 4 | Algorithms for Molecular Biology

Figure 4

From: Estimating the evidence of selection and the reliability of inference in unigenic evolution

Figure 4

A Comparison of EoS values with Prior Work. Comparison of the EoS value with the χ 1 2 statistics of prior work. (A) A per-site comparison of EoS values (left, red) with χ 1 2 statistics (blue, right). Both values are plotted such that larger values roughly indicate 'greater significance'. (B) EoS and χ 1 2 values are highly though non-linearly correlated, but are not comparable in terms of 'significance'. Specifically, while only 10/266 sites exceed the χ 1 2 critical value of p < 0.05 as shown by the blue horizontal line, 41/266 sites showed a posterior odds ratio of 20:1 or greater as shown by the red vertical line. We emphasize that binning adjacent sites would increase the specificity of the χ2 statistic at the cost of considerable sensitivity as per Behrsin et al. [7], and that 20:1 odds ratios are only roughly comparable to p values of 0.05.

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