Estimating the evidence of selection and the reliability of inference in unigenic evolution

Table 1 Sample Misincorporation Counts Under H₀

Sample mutagenic PCR counts C for 30 cycles of mutagenic PCR on the 798-nucleotide wild-type sequence for the I-Bmol homing endonuclease, as sequenced from 87 clones. Matrix entry C_ij represents the number of observed misincorporations from wild-type nucleotide j to clone-type nucleotide i in the 'unselected' population (top). For comparative purposes, misincorporation counts from the 'selected' population are also presented (bottom) although these are not used to estimate parameter matrix T.

ISSN: 1748-7188