Interpretation of ensembles on real data. A) Lasso tests on 9ilb:124-132 classifies 2 structures as non-variable (pink, yellow). B) For the same loop, structures classified as truly variable (red, cyan, green) deviate more from the PDB structure (black). C) Trajectory of the solution can give qualitative knowledge of the landscape in the vicinity of the native structure. All density maps are contoured at 1.5σ for clarity. Figures were generated using PyMol .