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Figure 5 | Algorithms for Molecular Biology

Figure 5

From: Efficient unfolding pattern recognition in single molecule force spectroscopy data

Figure 5

Top: In an F-D curve, the distance (tip sample separation) may be increasing or constant along the x -axis. The force may be increasing or decreasing or constant along the y-axis. A point in the F-D curve can be described as a pair, describing the changes of distance and force, as shown in brackets. To determine the changes along x and y axes, we get the derivatives and we discretise them. Bottom: An F-D curve can be described as a sequence of fragments describing the changes. Fragment A is local maximum force, which may be a main or side peak in the F-D curve. Fragment B is local minimum force, which separates two unfolding events in the F-D curve. Fragment C is increasing or decreasing force interrupted by a cliff of constant force, which may be a side peak in the F-D curve.

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