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Table 1 Unfolding of transmembrane helices in bR results in different unfolding pathways.

From: Efficient unfolding pattern recognition in single molecule force spectroscopy data

Region 1

(Helices E&D)

Region 2

(Helices B&C)

Region 3

(Helix A)

Unfolding pathways

(1 0 0)

(1 0 0)

 

100 100 10/11

(1 1 0)

(1 1 0)

(1 0)

100 110 10/11

(1 0 1)

(1 0 1)

(1 1)

100 101 10/11

(1 1 1)

(1 1 1)

 

100 111 10/11

  

Total

8

  1. The table shows the different unfolding pathways that are observable in the membrane protein bR. Sign "1" represents the presence of an event in the corresponding region, while "0" means no event. The analysis leads to 8 different unfolding pathways. The first unfolding pathway is given by the pattern 100 100 10, the second by the pattern 100 100 11, which means that in the third region we have two peaks, corresponding to the stepwise unfolding of helix A.
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Algorithms for Molecular Biology

ISSN: 1748-7188