Figure 1

An example of structued motifs This motif is observed on the protein Ferredoxin-NADP reductase [Swiss-Prot: P10933] and additional 150 Oxidoreductase FAD/NAD(P)-binding proteins from the InterPro entry [InterPro: IPR001433]. The motif is consisted of three local conserved regions 'R-x-Y-S', 'G-x-G-x(2)-P', and 'Y-x-C-G', interleaved by two large gaps x(54,96) and x(65,111). When these three pattern blocks are mapped onto the 3D structure of Ferredoxin-NADP reductase, it is shown that all the three blocks are close to the FAD/NAD(P) binding site. Pattern blocks are plotted in sticks using different colors. The long gap between the first and the second blocks (the second and the third blocks) is plotted with ribbons in orange (purple). The ligands FAD and NADP are shown as ball-and-stick in blue and red, respectively.