ProCEM vs. EFP computation. Left: Number of ProCEMs and EFPs computed for random subnetworks of different sizes. Right: The computation times (per second) required for computing the ProCEMs and EFPs in the left chart. ▲: ProCEMs; O: EFPs. Each experiment is repeated 100 times. Confidence intervals in this plot are based on one-sample t-test (95% c.i.). For large subnetworks (r > 40), we did not compute the EFPs because the program was very slow.