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Figure 6 | Algorithms for Molecular Biology

Figure 6

From: Getting DNA copy numbers without control samples

Figure 6

ROC comparison with scaled data (Lung Cancer dataset, sample GSM638958, hybridized to GenomeWideSNP 6.0 array). We have used the region where there is a change from 2 to 3 copies, around position 30Mb, that appears in Figure5. For the analysis, we have included the SNPs that surrounds the copy number change (specifically from 0 to 45 Mb). The SNPs within a safety zone from 25Mb to 35 Mb are not considered in the analysis because it is difficult to discern the exact position of the change. The SNPs located upstream the change point are considered to have total CNs smaller than the SNPs downstream the change point. For this particular sample (in the studied jump), NSA differentiates the two regions better than MHS.

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