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Figure 8 | Algorithms for Molecular Biology

Figure 8

From: Getting DNA copy numbers without control samples

Figure 8

ROC comparison with scaled data (Lung Cancer dataset, sample GSM639066, hybridized to GenomeWideSNP 6.0 array). We have used the region where there is a change from 3 to 2 copies, around position 65Mb, that appears in Figure7. For the analysis, we have included the SNPs that surrounds the copy number change (specifically from 0 to 100 Mb). The SNPs within a safety zone from 60 Mb to 75 Mb are not considered in the analysis since includes a deleted region. The SNPs located upstream the change point are considered to have total CNs larger than the SNPs downstream the change point. For this particular sample (in the studied jump), NSA differentiates better than MHS between the two regions.

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