Deviation from additivity and stochastic error. (a) ΔJC is portrayed (green) in the homogeneous sub-model of K2P with R =10 in the interval t ∈[0.8,2]. Its linear interpolation in that interval, Δint=At + B, is plotted in blue, and the maximum difference between the two functions is designated by X. The deviation of ΔJC from additivity in this setting is. (b) The affine-additive SR function minimizing its deviation from ΔJC is. The two SR functions ΔJC and Δ∗ are shown with their stochastic error margins, assuming sequence length of 500 bp.