Figure 1

Deviation from additivity and stochastic error. (a) Δ_JC is portrayed (green) in the homogeneous sub-model of K2P with R =10 in the interval t ∈[0.8,2]. Its linear interpolation in that interval, Δ_int=At + B, is plotted in blue, and the maximum difference between the two functions is designated by X. The deviation of Δ_JC from additivity in this setting is$\frac{X}{2A}$. (b) The affine-additive SR function minimizing its deviation from Δ_JC is${\Delta }^{\ast }={\Delta }_{\text{int}}+\frac{1}{2}X$. The two SR functions Δ_JC and Δ^∗ are shown with their stochastic error margins, assuming sequence length of 500 bp.