Figure 3

Results of iterative TbT approach. (a) Procedure for iterative TbT approach until the third iteration, and simulation results under P_A = (b) 50%, (c) 70%, and (d) 90%, with P_DEG = 20%. Left panel: accuracies of DEG identifications when step 2 in our DEG elimination strategy is performed using the following normalization factors: TMM (Default), TbT (First), TbT1 (Second), and TbT2 (Third). Right panel: AUC values when the following normalization factors are combined with the edgeR package: TbT (Default), TbT1 (First), TbT2 (Second), and TbT3 (Third).