E. coli: GntR motif ROC curves. ROC curves (plotted for 0≤sFPR≤0.1) for the most likely E.coli GntR motif, as chosen using the known width (left), MCOIN (centre) and E-values based estimator (right). The curve colour illustrates the threshold of p(Z
,θ), from 1.0 (red) to 0.0 (blue). All three estimators predict the GntR motif much better than expected, considering the low conservation of the motif and the results of the experiments using realistic synthetic data.