Table 4 Statistically enriched KEGG pathway terms for differentially expressed and coexpressed targets of TRANSFAC matrices V$NFAT1_Q6, V$OCT1_03, V$CREB_01, V$CREBATF_Q6, V$E2F_Q2 and V$SP1_Q6_01
Tricluster | TRANSFAC matrix | KEGG pathway terms (corrected p-value ≤ 0.05) |
|---|---|---|
4 | V$NFAT1_Q6 | KEGG: 00471: D-Glutamine and D-glutamate metabolism (GLS), KEGG: 04310: Wnt signaling pathway (PPP2R1B, ROCK1, TBL1X), KEGG: 04350: TGF-beta signaling pathway (ROCK1, TBL1X), |
4 | V$OCT1_03 | KEGG: 04961: Endocrine and other factor-regulated calcium reabsorption (SLC8A1, ESR1) |
17 | V$CREB_01 | KEGG: 00030: Pentose phosphate pathway (RBKS), KEGG: 04012: ErbB signaling pathway (PAK1), KEGG: 05211: Renal cell carcinoma (PAK1) |
17 | V$CREBATF_Q6 | KEGG: 04660: T cell receptor signaling pathway (PAK1), KEGG: 04650: Natural killer cell mediated cytotoxicity (PAK1, KEGG: 05120: Epithelial cell signaling in Helicobacter pylori infection (PAK1), KEGG: 04360: Axon guidance (PAK1) |
26 | V$E2F_Q2 | KEGG: 04110: Cell cycle (MCM7, ANAPC1, WEE1), KEGG: 03030: DNA replication (MCM7, POLA1) |
26 | V$SP1_Q6_01 | KEGG: 00100: Steroid biosynthesis (SQLE), KEGG: 00270: Cysteine and methionine metabolism (MAT2A), KEGG: 04962: Vasopressin-regulated water reabsorption (CREB1), KEGG: 04623: Cytosolic DNA-sensing pathway (MAVS) |