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Figure 4 | Algorithms for Molecular Biology

Figure 4

From: Predicting gene ontology annotations of orphan GWAS genes using protein-protein interactions

Figure 4

Comparison of the proposed method with randomized PPI network. Figures (A) and (B) show the comparison of precision-recall curves between the proposed method (for each of the five genesets) and a randomized PPI network constructed exploiting the GO DAG structure for (A) for CC GO terms and (B) MF GO terms. Figures (C) and (D) show the comparison of average precision-recall curves between the proposed method (averaged over 5 genesets) and a randomized PPI network for (C) CC GO terms and (D) MF GO terms. Figures (E) and (F) show the comparison of F-score versus threshold curves, between the proposed method and a randomized PPI network for (E) CC GO terms and (F) MF GO terms. F-score is calculated as the harmonic mean of precision and recall values.

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