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Table 2 CpG hypo-methylation in tissue-specific lncRNA promoters

From: Mutual enrichment in ranked lists and the statistical assessment of position weight matrix motifs

Tissue

Mutual enrichment between GC content and tissue-specificity

Mutual enrichment between hypo-methylation and tissue-specificity

Normal/subnormal cells

Cancer cells

Thyroid

3.89e-31

No methylation data

No methylation data

Prostate

5.76e-22

4.16e-11 (PrEC)

0.002 (LNCaP)

Adrenal

5.46e-20

No methylation data

No methylation data

Brain

1.57e-14

1.21e-8 (NH-A)

5.55e-5 (U87)

Ovary

8.80e-12

No methylation data

0.0085 (ovcar-3)

Lymph node

3.64e-6

No methylation data

No methylation data

Adipose

9.25e-6

No methylation data

No methylation data

Foreskin

2.25e-5

0.72 (BJ)

No methylation data

Breast

4.40e-5

5.08e-5 (HMEC)

8.45e-5 (MCF7)

2.0e-10 (MCF10A)

0.0065 (T-47D)

Kidney

6.34e-5

1.56e-5 (HEK293)

No methylation data

White blood cell

3.78e-4

0.6 (GM12878)

0.21 (Jurkat)

Placenta

0.011

No methylation data

No methylation data

Colon

0.012

No methylation data

1.0 (Caco-2)

Skeletal muscle

0.04

0.34 (SKMC)

No methylation data

Lung

0.33

No methylation data

No methylation data

Heart

1.0

1.0 (HCM)

No methylation data

1.0 (HCF)

Liver

1.0

1.0 (Hepatocytes)

1.0 (HepG2)

Testes

1.0

No methylation data

1.0 (NT2-D1)

Lung fibroblasts

1.0

1.0 (IMR90)

No methylation data

  

1.0 (AGO4450)

 
  1. We calculated the mutual enrichment between DNA hypo-methylation and tissue specificity for the lncRNA promoters. CpG methylation data was taken from UCSC Table Browser [39] (ENCODE/HAIB).