Our approach identifies densely interacting domains across scales. (a) Our algorithm discovers domains with mean frequency value for inter- and intra-domain interactions (solid lines) at or better than that of Dixon et al. domains (dotted lines). Each solid line represents domains at different resolution γ in human fibroblast cells. (b) Multiscale domains identified in human fibroblast cells by our dynamic program tend to have higher mean frequency than those of Dixon et al. (distributions are plotted after outliers >μ+4σ were removed).