Domain persistence across scales. (a) Domains identified by our algorithm (black) are smaller at higher resolutions and merge to form larger domains at γ close to 0. Visual inspection shows qualitative differences between consensus domains (red) and domains reported by Dixon et al. (green). Data shown for the first 4Mb of chromosome 1. (b) Variation of information for domains identified by our algorithm across different resolutions for chromosome 1 in human fibroblast cells.