Figure 5

Graph-distance distribution of the Drosophila melanogaster and the genomic RNA of human Coronavirus 229E. (A): Distribution of graph-distances (a = b = 1) in Drosophila melanogaster pre-mRNAs between the first and last intron position. To save computational resources, pre-mRNAs were truncated to 100 nt flanking sequence of introns. The black curve shows the graph-distance distribution computed for the corresponding pairs of positions on sequences that were randomized by di-nucleotide shuffling. (B): Graph-distances (a = b = 1) within and between the 5’ and 3’ regions of the genomic RNA of human Coronavirus 229E computed from a concatenation of position 1–576 (5’ UTR) and 25188–25688 (upstream of gene N). Secondary structures bring the 5’ TRS-L (63–76) and 3’ TRS-B (-23– -10) elements into close proximity.