Model
| | |
Single KOs
|
Double KOs
|
|---|
| |
ub
|
classes
|
Impact
|
Impact
|
ratio
|
|---|
E. coli iJO1366 | 1718 | 1078 | 4.51 (16.6) | 4.41 (10.1) | 1.0% |
E. coli iAF1260 | 1543 | 975 | 4.12 (13.7) | 4.04 (9.24) | 0.8% |
S. cerevisiae iND750 | 631 | 371 | 5.42 (14.6) | 5.52 (10.3) | 2.7% |
M. tuberculosis iNJ661 | 744 | 370 | 4.74 (35.6) | 1.99 (5.78) | 5.1% |
S. aureus iSB619 | 465 | 207 | 11.7 (44.9) | 7.31 (17.2) | 9.2% |
H. pylori iIT341 | 436 | 150 | 6.65 (58.6) | 4.71 (15.5) | 9.7% |
E. coli textbook | 87 | 55 | 1.96 (3.58) | 15.7 (24.5) | 12% |
-
ub: Number of unblocked reactions in the original network.
-
classes: Number of different reaction classes, i.e., equivalence classes w.r.t. partial coupling ⇔.
-
Single KOs impact: Average impact of single reaction knockouts, i.e., average number of reactions classes that become blocked by a single knockout. In brackets: Average number of reactions that become blocked (belonging to different reaction classes).
-
Double KOs impact: Average additional impact of double reaction knockouts, i.e., average number of reactions classes that become blocked by a double knockout {r, s}, but are not blocked by a single knockout of either r or s. In brackets: Average number of additional reactions that become blocked.
-
Double KOs ratio: Percentage of pairs of (uncoupled) reaction classes that have joint coupling effects. The average numbers are determined by \(\boldsymbol {\frac {1}{|K|}\sum _{\kappa \in K}\text {impact}\;(\kappa)}\) with K =Rep for the single, and K = {{r, s} | r, s ∈Rep with neither r
\(\boldsymbol {\stackrel {=0}{\rightarrow }}\)
s in L nor s
\(\boldsymbol {\stackrel {=0}{\rightarrow }}\)
r for the double knockouts.
