Double and multiple knockout simulations for genome-scale metabolic network reconstructions

Table 2 Average number of knockout options

Single KOs options: Average number of reactions r that lead as single knockouts to inactivity of a target reaction t: \(\boldsymbol {\frac {1}{|1_{L}|} \sum _{t\in 1_{L}}\sum _{r\stackrel {=0}{\rightarrow } t\,\text {in}\, L}}\) 1.
Double KOs options: Average number of uncoupled reaction pairs {r, s} that lead as double knockouts to inactivity of a target reaction t: \(\boldsymbol {\frac {1}{|1_{L}|} \sum _{t\in 1_{L}}\sum _{\{r, s\} \stackrel {=0}{\rightarrow }t\, \text {in}\,L}}\) 1.

ISSN: 1748-7188