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Table 2 Key results achieved for HIV-1 and HCV

From: An integrative approach for a network based meta-analysis of viral RNAi screens

Virus Subnetwork Predicted novel host factors
HIV HIV_s52  
   ∙ KDM4B - lysine-specific demethylase 4B
   ∙ HNRNPK - Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP)
   ∙ HNRNPL - Heterogeneous nuclear ribonucleoprotein L
   ∙ HNRNPM - Heterogeneous nuclear ribonucleoprotein M
   ∙ HNRNPU - Heterogeneous nuclear ribonucleoproteinU (hnRNP U) (Scaffold attachment factor A) (SAF-A) (p120) (pp120)
   ∙ RBM11 - Splicing regulator RBM11 (RNA-binding motif protein 11)
   ∙ RBM41 - RNA-binding protein 41 (RNA-binding motif protein 41)
   ∙ RBM42 - RNA-binding protein 42 (RNA-binding motif protein 42)
   ∙ RBM4B - RNA-binding protein 4B (RNA-binding motif protein 30) (RNA-binding motif protein 4B) (RNA-binding protein 30)
   ∙ ‘RBM7 - RNA-binding protein 7 (RNA-binding motif protein 7)
   ∙ SRSF3 - Serine/arginine-rich splicing factor 3 (PremRNA-splicing factor SRP20) (Splicing factor, arginine/serine-rich 3),
   ∙ SRSF4 - Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor,
   arginine/serine-rich 4)
   ∙ SRSF10 - Serine/arginine-rich splicing factor 10 (40 kDa SR-repressor protein)
HCV HCV_s43  
  α β Crystallin Complex subunits (CRYBAA, CRYBAB, CRYBA1, CRYBA2, CRYBA4, CRYBA1, CRYBB1, CRYBB2, CRYBB3)
   ∙ Heat-shock proteins (HspB1, HspB2, HspB6, HspB7 and HspB8)
   ∙ Tyrosine-protein phosphatase non-receptors, various types (PTP-1B, TCPTP, PTP-H1, PTPase MEG2)
   ∙ Tankyrase-1 (Poly-ADP-ribosyltransferase)
  1. The table shows the main novel findings for HIV-1 and hepatitis C virus obtained by mapping RNAi data to protein interaction networks, and using the clustering and filtering procedure proposed here. Results for the combined analysis are given in Additional file 5.