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Table 2 Key results achieved for HIV-1 and HCV

From: An integrative approach for a network based meta-analysis of viral RNAi screens

Virus

Subnetwork

Predicted novel host factors

HIV

HIV_s52

 
  

∙ KDM4B - lysine-specific demethylase 4B

 

HIV_s66

 
  

∙ HNRNPK - Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP)

  

∙ HNRNPL - Heterogeneous nuclear ribonucleoprotein L

  

∙ HNRNPM - Heterogeneous nuclear ribonucleoprotein M

  

∙ HNRNPU - Heterogeneous nuclear ribonucleoproteinU (hnRNP U) (Scaffold attachment factor A) (SAF-A) (p120) (pp120)

  

∙ RBM11 - Splicing regulator RBM11 (RNA-binding motif protein 11)

  

∙ RBM41 - RNA-binding protein 41 (RNA-binding motif protein 41)

  

∙ RBM42 - RNA-binding protein 42 (RNA-binding motif protein 42)

  

∙ RBM4B - RNA-binding protein 4B (RNA-binding motif protein 30) (RNA-binding motif protein 4B) (RNA-binding protein 30)

  

∙ ‘RBM7 - RNA-binding protein 7 (RNA-binding motif protein 7)

  

∙ SRSF3 - Serine/arginine-rich splicing factor 3 (PremRNA-splicing factor SRP20) (Splicing factor, arginine/serine-rich 3),

  

∙ SRSF4 - Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor,

  

arginine/serine-rich 4)

  

∙ SRSF10 - Serine/arginine-rich splicing factor 10 (40 kDa SR-repressor protein)

HCV

HCV_s43

 
  

∙ α β Crystallin Complex subunits (CRYBAA, CRYBAB, CRYBA1, CRYBA2, CRYBA4, CRYBA1, CRYBB1, CRYBB2, CRYBB3)

  

∙ Heat-shock proteins (HspB1, HspB2, HspB6, HspB7 and HspB8)

 

HCV_s64

 
  

∙ Tyrosine-protein phosphatase non-receptors, various types (PTP-1B, TCPTP, PTP-H1, PTPase MEG2)

  

∙ Tankyrase-1 (Poly-ADP-ribosyltransferase)

  1. The table shows the main novel findings for HIV-1 and hepatitis C virus obtained by mapping RNAi data to protein interaction networks, and using the clustering and filtering procedure proposed here. Results for the combined analysis are given in Additional file 5.