A multiobjective approach for identifying protein complexes and studying their association in multiple disorders

Table 5 Some useful metrics of disorder associated genes

Disease category	No. of associated genes	No. of interaction in human PPI	Density	Semantic similarity
Bone	180	94	0.0163	0.5676
Cancer	869	725	0.0019	0.8931
Cardiovascular	332	457	0.0083	0.7374
Connective_tissue	149	75	0.0068	0.7146
Dermatological	270	154	0.0042	0.6381
Developmental	143	219	0.0216	0.7589
Ear, nose, throat	177	183	0.0117	0.8277
Endocrine	305	572	0.0123	0.8432
Gastrointestinal	110	52	0.0087	0.5819
Hematological	389	755	0.0100	0.6449
Immunological	290	658	0.0157	0.8159
Metabolic	638	2,088	0.0103	0.7458
Muscular	294	1,183	0.0275	0.6421
Neurological	917	898	0.0021	0.7811
Nutritional	51	82	0.0643	0.6536
Ophthalmological	563	555	0.0037	0.7035
Psychiatric	75	49	0.0177	0.7032
Renal	170	131	0.0091	0.6545
Respiratory	79	1	0.00032	0.7023
Skeletal	278	186	0.0048	0.6679
Unclassified	64	6	0.0030	0.5080
Multiple	721	427	0.0016	0.8019

ISSN: 1748-7188