Fig. 3From: RNA folding with hard and soft constraintsTheophylline ligand binding to RNA structure motif using the soft constraints framework. a The core motif of the aptamer conformation. b Core motif abstraction to a simple interior loop suitable for the soft constraints framework. c Shift in predicted equilibrium base pair probabilities from ligand free prediction (upper arcs), to prediction with bound theophylline (lower arcs) for an artificial RNA sequence taken from [58]Back to article page