Comparison of predicted contacts for a typical domain sized protein (160 residues). The observed residue contacts are plotted in green and as the plot is symmetric the same contacts appear either side of the diagonal. In the top-left half, contacts predicted by the generic measure of conserved hydrophobicity are plotted in red which produces a characteristic “tartan” pattern. Contacts predicted using the correlated substitution method (PSICOV) are plotted in the lower-right half. These predicted contacts exhibit a clear pattern of diagonal and cross-diagonal stripes that are a much better match to the observed packing.