Fig. 7
From: Implications of non-uniqueness in phylogenetic deconvolution of bulk DNA samples of tumors
PhyloWGS and Canopy do not sample uniformly from the solution space. We consider an \(n=7\) instance (#81) with varying number \(m \in \{1,2,5,10\}\) of bulk samples (columns), from which we sample solutions using different methods (rows). Each plot shows the relative frequency (y-axis) of identical trees (x-axis) output by each method, with the simulated tree indicated by ‘\(\star\)’. While blue bars are correct solutions [satisfying (SC)], red bars correspond to incorrect solutions [violating (SC)]. Dashed line indicates the expected relative frequency in the case of uniformity. The title of each plot lists the number of incorrect solutions, the number of recovered correct solutions, the total number of correct solutions and the p-value of the chi-squared test of uniformity (null hypothesis is that the samples come from a uniform distribution)