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Fig. 5 | Algorithms for Molecular Biology

Fig. 5

From: TMRS: an algorithm for computing the time to the most recent substitution event from a multiple alignment column

Fig. 5

Effect of filtering. We investigated the effect of filtering by q threshold on the accuracy of \(t_{\text {MRS}}\) estimates using simulation dataset. The x-axis represents the fraction of alignment columns remained by filtering with varying threshold. a Fraction of alignment columns that have no mutation throughout the target lineage in the positive set. b Mean % error of \(t_{\text {MRS}}\) values in the dataset after filtering. The blue and green points represent the approximate \(t_{\text {MRS}}\) and q computed from the reconstruction of ancestral states, and the closest extant species whose base is different from that of the target species, respectively

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