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Table 4 Effects of filtering by probability q of no mutation

From: TMRS: an algorithm for computing the time to the most recent substitution event from a multiple alignment column

q threshold

Positive fraction

FDR for no mutation

% error of \(t_{\text {MRS}}\)

0.01

0.24

0.0013

4.4

0.1

0.36

0.015

7.9

0.5

0.68

0.16

15

1.0

1

0.33

15

  1. We computed a few statistical measures for the simulation dataset obtained by forward sampling of base mutation history. The first column represents the threshold values \(q_{\text {threshold}}\). ‘positive fraction’ represents the fraction of alignment columns with \(q < q_{\text {threshold}}\). ‘FDR for no mutation’ represents the fraction of the alignment columns that have no mutation along the target lineage but satisfy \(q<q_{\text {threshold}}\). ‘% error of \(t_{\text {MRS}}\)’ represents the mean % error of estimated \(t_{\text {MRS}}\) relative to the total edge length of the target lineage
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Algorithms for Molecular Biology

ISSN: 1748-7188