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Table 7 Tissue-concestor interval correlation for transcribed enhancers

From: TMRS: an algorithm for computing the time to the most recent substitution event from a multiple alignment column

Tissue

Interval

Z-score

\(-\log _{10}(\text {p-value})\)

Enrichment

Observed

Brain

Homo–Vertebrata

14.2

32.0

2.97

140

Hominoidea–Tetrapoda

13.3

29.2

2.69

148

Hominoidea–Vertebrata

11.5

22.1

2.17

115

Meninx

Hominoidea–Tetrapoda

8.58

11.7

3.84

32

Hominoidea–Vertebrata

6.68

7.72

3.52

23

Hominoidea–Amniota

6.06

6.96

3.01

25

Eye

Hominoidea–Vertebrata

8.43

11.5

3.50

37

Eutheria–Tetrapoda

8.42

7.44

9.69

9

Eutheria–Vertebrata

8.06

8.98

5.13

19

  1. The top three tissues that have transcribed enhancers with sites corresponding to specific concestor intervals are shown. Within each tissue, the top three concestor intervals are shown. The sorting order is based on Z-scores that are based on the hypergeometric test and indicate the significance of enrichment of specific concestor intervals in tissue-specific enhancers. ‘\(-\log _{10}(\text {p-value})\)’ is the minus log10 p-value of the test computed using the phyper() function in the R programming language. ‘Enrichment’ is the fold enrichment within the concestor interval relative to the expected occurrence by random sampling. ‘Observed’ is the number of transcribed enhancers that have both attributes of the Tissue and Interval columns. see Section 8 in Additional file 1 about the use of Z-scores for ranking tissues
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Algorithms for Molecular Biology

ISSN: 1748-7188