Skip to main content

Advertisement

Table 7 Tissue-concestor interval correlation for transcribed enhancers

From: TMRS: an algorithm for computing the time to the most recent substitution event from a multiple alignment column

TissueIntervalZ-score\(-\log _{10}(\text {p-value})\)EnrichmentObserved
BrainHomo–Vertebrata14.232.02.97140
Hominoidea–Tetrapoda13.329.22.69148
Hominoidea–Vertebrata11.522.12.17115
MeninxHominoidea–Tetrapoda8.5811.73.8432
Hominoidea–Vertebrata6.687.723.5223
Hominoidea–Amniota6.066.963.0125
EyeHominoidea–Vertebrata8.4311.53.5037
Eutheria–Tetrapoda8.427.449.699
Eutheria–Vertebrata8.068.985.1319
  1. The top three tissues that have transcribed enhancers with sites corresponding to specific concestor intervals are shown. Within each tissue, the top three concestor intervals are shown. The sorting order is based on Z-scores that are based on the hypergeometric test and indicate the significance of enrichment of specific concestor intervals in tissue-specific enhancers. ‘\(-\log _{10}(\text {p-value})\)’ is the minus log10 p-value of the test computed using the phyper() function in the R programming language. ‘Enrichment’ is the fold enrichment within the concestor interval relative to the expected occurrence by random sampling. ‘Observed’ is the number of transcribed enhancers that have both attributes of the Tissue and Interval columns. see Section 8 in Additional file 1 about the use of Z-scores for ranking tissues