Table 7 SERES + GUIDANCE2 performance using alternative methods for estimating an input MSA
Model condition | PR-AUC (%) | |||||
|---|---|---|---|---|---|---|
ClustalW | FSA | |||||
GUIDANCE2 | SERES + GUIDANCE2 | Pairwise t-test corrected q-value | GUIDANCE2 | SERES + GUIDANCE2 | Pairwise t-test corrected q-value | |
10.A | 95.37 | 95.78 | \(2.8 \times 10^{-3}\) | 96.36 | 96.55 | \(8.6 \times 10^{-3}\) |
10.B | 92.30 | 92.95 | \(8.2 \times 10^{-4}\) | 95.40 | 95.87 | \(4.9 \times 10^{-3}\) |
10.C | 89.36 | 91.23 | \(1.7 \times 10^{-4}\) | 95.32 | 96.06 | \(2.7 \times 10^{-3}\) |
10.D | 88.53 | 90.45 | \(8.8 \times 10^{-5}\) | 96.21 | 96.87 | \(2.1 \times 10^{-3}\) |
10.E | 73.96 | 76.50 | \(8.2 \times 10^{-4}\) | 90.23 | 92.51 | \(8.6 \times 10^{-3}\) |
Model condition | ROC-AUC (%) | |||||
|---|---|---|---|---|---|---|
ClustalW | FSA | |||||
GUIDANCE2 | SERES + GUIDANCE2 | DeLong et al. test corrected q-value | GUIDANCE2 | SERES + GUIDANCE2 | DeLong et al. test corrected q-value | |
10.A | 96.99 | 97.23 | \(<10^{-10}\) | 80.85 | 81.61 | \(<10^{-10}\) |
10.B | 96.64 | 96.94 | \(<10^{-10}\) | 81.31 | 82.89 | \(<10^{-10}\) |
10.C | 96.27 | 96.88 | \(<10^{-10}\) | 84.48 | 86.56 | \(<10^{-10}\) |
10.D | 95.78 | 96.65 | \(<10^{-10}\) | 88.63 | 90.37 | \(<10^{-10}\) |
10.E | 89.84 | 90.80 | \(<10^{-10}\) | 89.10 | 90.83 | \(<10^{-10}\) |