Fig. 1

A schematic diagram of herpesvirus miRNA motif occurring on a human circRNA. As indicated in the legend, each thin circle represents a circRNA; each thick line segment, the occurrence of a miRNA motif on the corresponding circRNA. Both circRNAs and the miRNA motif have nucleotide sequences represented by IUPAC codes (A, C, G, U). This figure illustrates occurrences of a single miRNA motif (e.g., UUACAGG) on the circRNAs. The biological question is: “does any circRNA have too many occurrences of the motif to be explained by chance alone?” In the actual application, the \(n = 3086\) circRNAs ranged in length from 69 nt to 158565 nt