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Fig. 6 | Algorithms for Molecular Biology

Fig. 6

From: Bayesian optimization with evolutionary and structure-based regularization for directed protein evolution

Fig. 6

Bayesian selection techniques quickly identify informative sequence patterns. Shown are the per-batch average position-specific entropy of variant selections under the top scoring model for each protein. These include (Top) GP + UCB + TPLM for GB1, (Middle) GP + EI + FoldX for BRCA1, and (Bottom) GP + UCB + FoldX for Spike. Lighter squares denote low entropy decisions, meaning the model selects among fewer residue types at that position in that batch

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Algorithms for Molecular Biology

ISSN: 1748-7188