Fig. 8
From: Heuristic shortest hyperpaths in cell signaling hypergraphs
Cyclic shortest hyperpath to phosphorylated p53 in the Reactome dataset. All vertices in the hyperpath connected to the supersource are shown at the top of the figure. The hyperedges in this hyperpath show the transcription of STK11 and p53 (TP53) before NUAK1 (ARK5) participates in the phosphorylation of the p53 tetramer. Hyperedges \(e_5\), \(e_6\), and \(e_7\), shown in red, create a cycle when the phosphorylation of p53 breaks up a complex, returning STK11 to its solitary state. Hyperedges \(e_2\) and \(e_3\) show transcription, and are drawn dotted