Fig. 9
From: Heuristic shortest hyperpaths in cell signaling hypergraphs
Cyclic shortest hyperpath to the HEY2/ARNT complex in the Large dataset. All vertices from the hyperpath connected to the supersource are shown at the top of the figure. Positive regulators of reactions are shown by dashed lines ending in a disc. The eleven hyperedges span three different NCI-PID pathways, and show the events upstream of HEY2 transcription, ultimately culminating in its repression of ARNT. The cycle between hyperedges \(e_9\) and \(e_{11}\), shown in red in the figure, recreates nuclear HIF1A. Edge \(e_8\), shown dotted, is a template reaction, where the NOTCH1/RBPJ complex upregulates the transcription of the protein HEY2