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Fig. 2 | Algorithms for Molecular Biology

Fig. 2

From: Bi-alignments with affine gaps costs

Fig. 2

Alignment (top) and Bi-alignment (bottom) of 145 N-terminal amino acids of two CYP1B1 cytochrome P450 enzymes: the extant human enzyme (Human 1B1) and the corresponding ancestral mammalian cytochrome (N98 1B1_M). See Fig. 1 for the representation of the alignments and secondary structure elements. Only the bi-alignment properly aligns the ’shifted’ fifth helix and explains the structural incongruence by evolutionary shifts (two forward and two backward shifts

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