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Figure 1 | Algorithms for Molecular Biology

Figure 1

From: Mimosa: Mixture model of co-expression to detect modulators of regulatory interaction

Figure 1

The figure illustrates the intuition behind Mimosa. Consider a TF gene X and a potential target gene Y. The expression values of X and Y for all expression samples are shown as a heat plot and as a scatter plot. We presume that X and Y expression are correlated only in an unknown subset of samples (depicted by "+") and not in the remaining samples (denoted by "-"). Mimosa computes the maximum likelihood partition of samples. Then given the sample partition, a third gene Z with differential expression between the two partitions may represent a potential modifier. To be precise, we assign a partition probability to each sample as opposed to a binary partition.

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